Accordingly, the researchers believe that the disruptive events (studied in Project 1 - Diabetogenic Mine Tailings: Mechanistic Link Between Arsenic, NRF2, Autophagy, and Diabetes) and the protective mechanisms (this project) mediated by Nrf2 signaling are both important determinants of the diabetogenic risk of mine tailing arsenic metalloids.Web
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An expert panel assembled by the National Toxicology Program in 2011 found animal research on the topic of arsenic and diabetes to be inconclusive, due …Web
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Introduction. Arsenic is a global health threat that contaminates drinking water, food, soil, and air for millions of people worldwide. There is significant evidence of the negative health consequences of arsenic exposure, including linkage to cancer, skin lesions, and cardiovascular disease (Kuo et al., 2017).There is also research that associates arsenic …Web
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The burden of diabetes is increasing globally. Identifying novel preventable risk factors is an urgent need. In 2011, the U.S. National Toxicological Program (NTP) conducted a workshop to evaluate the epidemiologic and experimental evidence on the relationship of environmental chemicals with obesity, diabetes, and metabolic syndrome. …Web
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Studies on the association between arsenic exposure and diabetes mellitus (DM) yielded inconsistent results. Epidemiologic data on the associations between arsenic exposures via inhalation and DM are limited. Therefore, we conducted a meta-analysis to …Web
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Both arsenic and low SES have previously been linked to type 2 diabetes, so Eick set out to evaluate whether arsenic-related diabetes risks differ between people with low and high SES. She used data from a self-reporting survey to estimate SES, which collected information such as ownership of appliances and cars.Web
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Maull et al. (2012) reviewed evidence linking arsenic with diabetes in an evaluation that I believe could divert research resources from where they should properly be allocated. I wish to make two points: The review gives credibility to flawed studies that conclude that the prevalence of diabetes is increased in people having urine arsenic …Web
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Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk …Web
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Introduction. Arsenic is a global health threat that contaminates drinking water, food, soil, and air for millions of people worldwide. There is significant evidence of the negative health consequences of arsenic exposure, including linkage to cancer, skin lesions, and cardiovascular disease (Kuo et al., 2017).There is also research that …Web
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Abstract. Chronic arsenic exposure has been suggested to contribute to diabetes development. We performed a systematic review of the …Web
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If you have a private well, test it for arsenic. The ministry of health or ministry of environment in your province or territory can tell you how to do this. If your arsenic level is above 0.01 milligrams per litre (0.01 mg/L) or 10 micrograms per litre (10 µg/L), stop drinking from the well and take steps to reduce the level of arsenic.Web
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In the present review, researchers including first author Felicia Castriota, then a PhD candidate at UC Berkeley, synthesized the findings of 47 in vivo and in vitro studies to highlight likely molecular …Web
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Abstract. Arsenic is a naturally occurring toxic metalloid of global concern. Many studies have indicated a dose–response relationship between accumulative arsenic exposure and the prevalence of diabetes mellitus (DM) in arseniasis-endemic areas in Taiwan and Bangladesh, where arsenic exposure occurs through drinking water.Web
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Arsenic Toxicity. Arsenic compounds are known to be very toxic and carcinogenic. Chronic exposure to arsenic has more effects on health than any other toxicant, and the list continues to grow. Arsenic poisoning takes between 8 and 14 years to manifest its effect on health, depending on the amount of arsenic ingested, nutritional …Web
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Arsenic could influence diabetes development by other mechanisms, including oxidative stress, inflammation, or apoptosis, nonspecific mechanisms that have been implicated in the pathogenesis of type 2 diabetes. Arsenic exposure can enhance the production of reactive oxygen species (Barchowsky et al. 1999; Chen et al. 1998; Tseng …Web
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See the article "Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family …Web
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Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk …Web
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Major diseases that have been linked to arsenic poisoning are diabetes, hyperkeratosis, cancer, hypertension, and neurodegeneration, etc. Meanwhile, to date, there is no specific or approved remedy for arsenic poisoning. Chelation therapy for the management of arsenic poisoning is fraught with several side effects which limit its …Web
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In particular, a somewhat increased risk for diabetes has been reported among people exposed to arsenic through drinking water.9, 10 The potential relationship between mortality from diabetes and chronic arsenic exposure via drinking water has also been evidenced.11 Indications of a relationship between arsenic exposure and diabetes …Web
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1. Introduction. Arsenic (As) is a common drinking water contaminant that is often found in groundwater wells [1–6].Even at very low concentrations, chronic consumption of As in drinking water has been strongly associated with a variety of cancers and other adverse health effects in humans [7–13].At least 226 million people in 56 countries are …Web
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Arsenic exposure remains an important threat to human health and an underappreciated contributor to the current epidemic of diabetes. This mouse model of chronic arsenic exposure provided additional insights into the links between arsenic exposure and metabolic dysfunction (Fig. 8). Despite normal patterns of total food intake …Web
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Furthermore, arsenic exposure can lead to the development of risk factors for CVD, such as diabetes mellitus and hypertension. Arsenic-induced various. Author statement. Arsenic is a king of poison and well-recognized environmental contaminant that occurs naturally through geogenic processes in the aquifer.Web
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The arsenic-associated type of diabetes mellitus was probably non-insulin-dependent diabetes mellitus (or Type 2 diabetes mellitus) clinically, because almost all of the study subjects included were above 30 years of age and the clinical diagnosis of diabetes mellitus as described by all of the studies favored such a clinical type of disease.Web
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Arsenic is linked to the development of both type 1 and 2 diabetes; the immune system may be a common mechanism (Liu et al. 2023).A systematic review and meta-analysis found that Arsenic exposure was associated with an increased risk of type 2 diabetes (Kakavandi et al. 2023).A review discusses the role of arsenic in diabetes, as well as …Web
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Arsenic Factsheet. Arsenic, a naturally occurring element, can combine with either inorganic or organic substances to form many different compounds. Inorganic arsenic compounds are in soils, sediments, and groundwater. These compounds occur either naturally, or as a result of mining, ore smelting, or when using arsenic for industrial …Web
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September 20, 2013 2:13 pm. Elementary school students in Seville, Calif., take a water break. Drinking water in many parts of California's Central Valley is contaminated with arsenic. Jim Wilson/The New York Times. The baby with the runny nose, the infant with a stubborn cough — respiratory infections in small children are a familiar family ...Web
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Associations of arsenic exposure with diabetes- and muscle mass-related parameters. Table S2 shows the associations of arsenic exposure with diabetes- and muscle mass-related parameters by linear regression analyses. In both male and subjects, arsenic exposure levels showed significant positive associations with the levels …Web
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Environmental pollutants acting as endocrine-disrupting chemicals (EDCs) are recognized as potential contributors to metabolic disease pathogenesis. One such pollutant, arsenic, contaminates the drinking water of ~100 million people globally and has been associated with insulin resistance and diabetes in epidemiological studies. Despite …Web
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