These magnetic fields have been found to penetrate the skin surface to a depth of 20 mm. 125 Further, neodymium-iron-boron has been used along with SPIONs to enhance magnetic drug targeting. 58, 59 Magnetic stents or implants, which can create strong local magnetic fields, have also been used to increase the concentration of drug …Web
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In the field of nanobiotechnology, MNPs are mature nanomaterials that can bind to cells and have long been used for in vitro separation with the help of an external magnetic field [].Antibody-functionalized MNPs, namely, immunomagnetic nanoparticles, are frequently applied in the biomedical field.Web
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Nanovectors of superparamagnetic iron oxide nanoparticles (SPION) are of tremendous significance in cancer therapy because of their inherited high surface area, …Web
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The combination of magnetic and plasmonic properties at the nanoscale promises the development of novel synergetic image-guided therapy strategies for the treatment of cancer and other diseases, but the fabrication of non-contaminated magneto-plasmonic nanocomposites suitable for biological applications is difficult within traditional …Web
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Magnetic nanomaterials belong to a class of highly-functionalizable tools for cancer therapy owing to their intrinsic magnetic properties and multifunctional design that provides a multimodal theranostics platform for cancer diagnosis, monitoring, and therapy.Web
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A typical lung cancer H1299 cells separation process in the FCS device was observed where all cells were flowed near the bottom sidewall of the channel and exited through outlets 1 and 2 in the absence of a magnetic field. A separation between H1299 cancer cells and WBCs was quite visible in the presence of a magnetic field.Web
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Download : Download high-res image (267KB) Download : Download full-size image Microplastic separation and degradation via magnetic nanomaterials are quite promising strategies. This review elucidates the up-to-date strategies of microplastic separation and degradation via various magnetic nanostructures, the adsorption interaction between …Web
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As the nanoparticle size further increases, the nanoparticles start to exhibit ferromagnetism as opposed to superparamagnetism, and generate strong magnetic fields that completely dephase nearby water protons which in turn are unable to contribute to the MR signal. 93 Furthermore, other factors such as aggregation due to lower stability, as ...Web
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Numerical results: (a) Two-dimensional distribution of the longitudinal magnetic field B Z of the permanent magnet.(b) B Z of the magnet on the Z-axis (X = 0 mm).∇ B (dB Z /dz) is approximately ...Web
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Metastasis of cancer is a major cause of death worldwide. Circulating tumor cells (CTCs) are important in the metastatic process of cancer. CTCs are able to circulate in the bloodstream. Therefore, they can be used as biomarkers of metastasis. However, CTCs are rare when compared to a large number of blood cells in the blood. Many CTC …Web
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1. Introduction Micro and nanoparticles (NPs) made from lipids, polymers, and metals have been used in biomedical applications for decades [ 1]. In recent years, various studies …Web
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Lung cancer is one of the serious malignant tumors with high morbidity and mortality due to the poor diagnosis and early metastasis. The developing nanotechnology provides novel concepts and research strategies for the lung cancer diagnosis by employing nanomaterials as diagnostic reagents to enhance diagnostic efficiency. This …Web
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Introduction. The development of magnetic nanoparticles (MNPs) is promising for numerous applications. The core-shell nanoparticle is mostly designed for targeted and controlled drug delivery. 1,2 MNPs can be manipulated through using magnetic fields, 3,4 and such procedure is categorized as a magnetic resonance …Web
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SERS‐Fluorescence Joint Spectral Encoded Magnetic Nanoprobes for Multiplex Cancer Cell Separation. Adv. healthc. mater. 3, 1889–1897 (2014). Article PubMed CAS Google ScholarWeb
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Furthermore, magnetic nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPIONs), can detect sentinel lymph nodes in breast cancer in a clinical setting, as well as those in gallbladder cancer in animal models, in a surgery-applicable timeframe. ... Protein purification and cell separation applications require …Web
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Simple Summary. For the enrichment of very rare cells, such as Circulating Tumor Cells (CTCs), immunomagnetic enrichment is frequently used. For this purpose, magnetic nanoparticles (MNPs) coated with specific antibodies directed against cancer cells are used. In this review, we look at the properties such a particle needs to have in …Web
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In this work, we have studied field-induced aggregation and magnetic separation—realized in a microfluidic channel equipped with a single magnetizable micropillar—of multicore iron oxide nanoparticles (IONPs) also called "nanoflowers" of an average size of 27 ± 4 nm and covered by either a citrate or polyethylene (PEG) …Web
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One biomarker conjugates with immunofunctionalized magnetic nanoparticles (MNPs), enabling the separation of the T helper cells from a mixed population of cells. The other biomarker is used for detection during enzyme-linked immunosorbent assay (ELISA) analysis.Web
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The preparation of pNIPAM-MAG-CNMs.A thermal-sensitive poly(N-isopropylacrylamide) (pNIPAM) is grafted with Fe 3 O 4 nanoparticles onto the carbon nanotubes' open ends using the surface-initiated atom transfer radical polymerization (SI-ATRP) method.The cavities of the nanotubes could transport both proteins and ions …Web
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The migration process of magnetic nanoparticles and colloids in solution under the influence of magnetic field gradients, which is also known as magnetophoresis, is an essential step in the separation technology used in various biomedical and engineering applications. Many works have demonstrated that in specific situations, separation can …Web
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In our previous study, Xu et al. [38] theoretically analyzed the advantages of magnetic nanoparticles (MNPs) in cancer cell isolation and confirmed the great potential of nanometer-sized MNPs in CTCs capture using iron oxide nanoparticles (27 nm) binding with anti-HER2 antibody. Recently, we systematically explored the size effects of …Web
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MNPs can be synthesized using various methods to produce nano- to micro-sized high-quality nanoparticles. Oxides of iron, including γ-Fe 2 O 3 and Fe 3 O 4, and pure standalone metals (namely iron and cobalt) have all been used to make magnetic nanoparticles.Many recent studies have demonstrated effective synthetic ways to fine …Web
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Magnetic recording applications require a large remanence, but other applications (such as magnetic nanoparticles for cancer treatment) prefer it to be as small as possible. 8.3.3 Domain Theory Magentic particles are composed of small regions called magnetic domains in which the local magnetization is saturated but not necessarily parallel.Web
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Fe 3 O 4 NPs are excellent nanoparticles for cancer therapy, ... The compound was washed continuously with excess methanol in order to remove the unreacted polymer after magnetic separation and dried under vacuum to obtain polymer-coated magnetic nanoparticles. ... The sample showed a strong absorption peak at 358 nm, …Web
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1. Introduction Cancer diagnosis and treatment have improved over the last years, leading to increased survival rates. Conventional strategies including surgery, …Web
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Magnetic nanoparticles were attached to leucocytes and mixed at 220 μl/ml cells for 10 min. The flow rate is 3 ml/h. The average recovery rate was 87% for 50 cells …Web
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Furthermore, nanoparticles based on metal elements gold, zinc [58], cobalt, manganese [59], and also magnetic nanoparticles are widely used to contribute to the heating efficiency for hyperthermic treatment [60].This treatment consists of heating tumor cells to a temperature range of 40–45 ºC, which is enough to destroy or induce apoptosis …Web
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Meanwhile, others have loaded cell-derived vesicles with magnetic nanoparticles and drug for cancer therapy: ... However, despite using an extremely strong magnetic field from a modified MRI, this method still required a 50 μm particle (Pouponneau et al., 2009, 2011). Similar catheter-aided approaches have used particles up to 1.5 mm in diameter.Web
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The ferrofluid, which is made up of Fe 3 O 4 nanoparticles (10 nm) suspended in water, generated a concentration difference in the separation channel; the higher the magnetic field gradient is, the higher the concentration of the Fe 3 O 4 nanoparticles, therefore the non-magnetic particles suspended in the ferrofluid are …Web
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Over the last decades, the use of magnetic particles, especially superparamagnetic MNPs [], in biomedical research has gained an incredible momentum due to unique features and modalities they offer in various areas such as imaging [], drug delivery [], magnetic separation, and purification [].Being an inherent T2 magnetic …Web
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Due to their biocompatibility and magnetic response, Fe 3 O 4 -based nanomaterials have been proposed for magnetic separation of biomolecules [12, 194], contrast agents in MRI [14,195,196] and ...Web
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