A more detailed picture of the environmental impact of aggregate mining is outlined in a 2005 legal challenge to the expansion of an existing quarry in the Niagara Escarpment. The report focuses on the following potential environmental impacts: Potential impairment of water quality on the site, including harm to the aquiferWeb
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Health Problems from Mining. Mining causes serious accidents such as fires, explosions, or collapsed mine tunnels that affect miners and people living in …Web
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About Associated Aggregates Inc. Associated Aggregates has been an Indigenous Alberta family owned and operated business since 1995, with over 30+ gravel pits in Central and Northern Alberta. Our gravel supplies cover all areas from Hinton to Smoky Lake to Red Deer and everywhere in between. We believe in maintaining high …Web
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Background: Evidence of the association of coal mining with health outcomes such as increased mortality and morbidity in the general population has been provided by epidemiological studies in the last 25 years. Given the diverse sources of data included to investigate different health outcomes in the exposed populations, the International …Web
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Mining continues to be a dangerous activity, whether large-scale industrial mining or small-scale artisanal mining. Not only are there accidents, but exposure to dust and toxins, along with stress from the working environment or managerial …Web
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Exposure to coal mine dust during mining can cause a spectrum of disease termed CMDLD. This spectrum includes classic forms of CWP and silicosis, mixed dust …Web
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As the exposed group showed lower lung function parameters than the control group, indicating that people living close to the quarry sites have a stronger possibility of developing lung disease. Previous studies that measured the lung function of people exposed to dust were only conducted among quarry or mining workers …Web
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Dysfunction of cellular homeostasis can lead to misfolding of proteins thus acquiring conformations prone to polymerization into pathological aggregates. This process is associated with several disorders, including neurodegenerative diseases, such as Parkinson's disease (PD), and endoplasmic reticulum storage disorders (ERSDs), like …Web
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Here, we show that diverse disease-associated aggregates sequester the highly abundant major chaperone heat shock cognate protein 70 (HSC70) to the point of functional collapse of an essential cellular process, clathrin-mediated endocytosis (CME). Importantly, aggregate-driven CME inhibition is reversible and can be rescued by …Web
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The infrastructure created by mining operations in remote, untouched landscapes can lead to improved access to these regions which may result in further human-caused disturbance to the local ecological systems. The impact of mining operations on the surrounding land is also closely linked to the ecological setting of the mining sites.Web
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Every year, 1.8 million years of ill-health, disability or early death can be attributed to the global burden of disease from mercury poisoning in artisanal small-scale gold mining. …Web
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We present aggregate results and analyses by region and disease. We estimate that approximately 100,000,000 occupational injuries (100,000 deaths) and 11,000,000 occupational diseases (700,000 ...Web
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In aggregate mining, the. ... be provided with personal protective equipment to prev ent hearing disorders ... or dolomite (CaMg(CO3)2). Mining is known to be associated with several ...Web
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Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration, disrupts cellular functions and leads to neuronal death. Mutations, posttranslational modifications, and truncations are common molecular underpinnings in the formation of aberrant protein conformations that seed aggregation. The major proteins …Web
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The sustainability of aggregate production is linked to the solution of complex environmental, social and societal issues associated with the exploration, mining, processing, transportation and recycling of aggregated resources and the reclamation of mined-out aggregate deposits . It is, therefore, necessary to research the processes …Web
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In secondary reactive amyloidosis and mouse senile amyloidosis, associated with deposition of amyloid-A and apolipoprotein AII, respectively, even tiny quantities of misfolded aggregates can be transmitted between individuals and cause disease by diverse routes, including blood transfusion and oral administration [73], [74].Web
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Since then, an increasing number of proteins and natural or synthetic peptides not associated with disease (reviewed in Ref. [5]) and of amino acid homopolymers [69] have deliberately been made to assemble in vitro into fibrillar and pre-fibrillar aggregates undistinguishable from those found in vivo. This happens under …Web
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3. Processing Chemicals Pollution. This kind of pollution occurs when chemical agents (such as cyanide or sulphuric acid used by mining companies to separate the target mineral from the ore) spill, leak, or leach from the mine site into nearby water bodies. These chemicals can be highly toxic to humans and wildlife. 4.Web
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This is followed by disease of cellular proliferation, which almost exclusively covers cancer–gene associations. By contrast, we find quite a few associations (7443) for disease of infectious agent, which come exclusively from text mining. The latter is to be expected, since the DISEASES database aims to identify causal associations between ...Web
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As an overview of the Mining Program Strategic Plan, 2019–2024, Table 1 represents these three strategic goals, along with their associated intermediate goals (IGs) and related NIOSH goals, in the context of a five-year planning horizon. Table 1. Mining Program Strategic Plan Overview, 2019-2024*. Strategic Goal 1.Web
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Several disease-associated proteins, however, are not intrinsically misfolded and only aggregate as a result of external triggers that can occur before age-dependent decline of the PQC system. ... the role of extracellular chaperones in handling extracellular aggregates and in dealing with prion-propagation of the disease-associated aggregates ...Web
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Previous studies have associated elevated mortality risk in central Appalachia with coal-mining activities, but few have explored how different non-coal factors influence the association within each county. Consequently, there is a knowledge gap in identifying effective ways to address health disparities in coal-mining counties. To specifically …Web
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Sand is a critical ingredient for many of the materials that we take for granted: concrete, glass and asphalt. Sand and coarse aggregates form the backbone of the modern world and also, through land reclamation, the ground on which we live. A growing global population increasingly living in cities has led to a spiralling rise in the …Web
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Surprisingly, reliable data on their extraction in certain developed countries are available only for recent years. Sand was until recently extracted in land quarries and riverbeds; however, a shift to marine and coastal aggregates mining has occurred due to the decline of inland resources. River and marine aggregates are now the main sources ...Web
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Progressive accumulation of specific protein aggregates is a defining feature of many major neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto-temporal dementia, Huntington's disease, and Creutzfeldt–Jakob disease (CJD).Findings from several recent studies have suggested that aggregation-prone …Web
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In a cross-sectional study using data from a health screening program for current and former New Mexico miners, log-binomial logistic regression models were used to estimate …Web
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Abstract. Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, which are common also in natural …Web
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Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology ...Web
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NIH Guide: MINING OCCUPATIONAL SAFETY AND HEALTH … Oct 22, 2001 · PURPOSE The Centers for Disease Control and Prevention ... many of the health and safety problems associated with mining will be ... such aggregate …Web
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Project-induced in-migration has also been identified as a major concern in mining regions that is associated with an array of health risks, including overburdened …Web
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Disease-associated aggregate components serve as diagnostic biomarkers for diverse neurodegenerative pathologies (Balasubramaniam et al., 2019; Ayyadevara et al., 2021). To evaluate the importance of these IDPs for aggregate formation and associated traits, we performed an initial screen in which IDPs from the DisProt …Web
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This is shown by the results of a survey of aggregates mining companies in Hoa Binh Province as well as on-site data collection to determine the technological characteristics of production facilities alongside economic and environmental factors. ... mining is always associated with environmental pollution and emissions, and always entails the ...Web
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