indium 111 vitro

Heterodimeric Radiotracer Targeting PSMA and GRPR for …

The heterodimers were labeled with indium-111 and evaluated in vitro. In the competitive binding assay, BQ7812, featuring phenylalanine and shorter PEG-linker, demonstrated a nine-fold improved affinity towards PSMA. ... [111 In]In-BQ7800. Herein, we showed that the affinity of a bispecific PSMA/GRPR heterodimer towards PSMA could be …Web

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Improvement of the Targeting of Radiolabeled and

Doubly fluorescent liposomes or doubly radiolabeled liposomes were, respectively, used for in vitro and in vivo studies. In each case, a tracer of the lipid bilayer [rhodamine or indium-111 ((111)In)] and a tracer of the aqueous phase [fluorescein or iodine-125 ((125)I)] were present.Web

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Indium Oxyquinoline: Package Insert

Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling autologous leukocytes. It is supplied as a sterile, non-pyrogenic, isotonic aqueous solution with a pH range of 6.5 to 7.5. Each mL of the solution contains 37 MBq, 1 mCi of indium In 111 [no carrier added, >1.85 GBq/µg indium (>50 mCi/µg …Web

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Characterization of 111 In-labeled Glucose-Dependent

Therefore, [Lys 37 (DTPA)]N-acetyl-GIP 1-42 was radiolabeled with 111 In with specific activity up to 1.2 TBq/µmol and both in vitro and in vivo receptor targeting properties were examined. In vitro, [Lys 37 (111 In-DTPA)]N-acetyl-GIP 1-42 showed receptor-mediated binding to BHK-GIPR positive cells, NES2Y cells and isolated islets. …Web

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An indium-111-labelled membrane-targeted peptide for cell …

In vitro results indicate that although [111 In]In-DTPA-CTP is an inferior cell labelling reagent compared to [111 In]In-(oxine) 3 in terms of retention of radiolabel, it can deliver sufficient indium-111 to cells to enable imaging; and that over short periods of time, significant amounts of [111 In]In-DTPA-CTP are retained by labelled cells.Web

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Indium-111 labeled platelets: Studies on preparation

The in vitro radiolabeling of platelets was originally performed with chromium-51 to monitor cellular kinetics. When oxine complexes radiolabeled with indium-111 were introduced, they allowed the study of abnormal platelet deposition in vivo. This is still the method of choice for the assessment of platelet survival and is also used to image ...Web

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Preliminary in vitro comparison of 111In and 131I labeled

Both indium-111 and iodine-131 were labeled onto nimotuzumab targeting EGFR which was over expressed in various tumors, with high radiochemical purity of …Web

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111

The integrin expression of the cultured T cells was determined by flow cytometry and in vitro adhesion was assessed in a mucosal addressin cell adhesion molecule 1 (MAdCAM-1) adhesion assay. We studied the homing pattern after autologous infusion of …Web

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Assay for Macrophage‐Mediated Anti‐Tumor Cytotoxicity

This unit describes a procedure for determining ability of mouse macrophages to lyse tumor cells in vitro. The outlines a three-stage assay that includes: (1) culture of macrophages (freshly explanted from mice or grown from a cell line) with suspected activating reagents; (2) extensive washing of the cultured macrophages to remove residual reagents, …Web

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Alpha radioimmunotherapy using 225Ac-proteus-DOTA for solid …

Pr was radiolabeled with 225 Ac and its imaging surrogate, 111 In. In vitro studies verified anti-DOTA scFv recognition of [225 Ac]Pr, and in vivo biodistribution and clearance studies were performed to evaluate hapten suitability and in vivo targeting efficiency. ... Indium Radioisotopes / administration & dosageWeb

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Indium-111 labeled gold nanoparticles for

The indium-111 labeled gold nanoparticles were synthesized using a simple procedure that allowed stable labeling of the nanoparticle core with various indium-111 activities. Subsequent surface modification of the particle cores with RGD-based ligands at various densities allowed for molecular targeting of the α v ß 3 integrin in-vitro and for ...Web

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Indium-111 labeled gold nanoparticles for

An indium-111 labeled gold nanoparticle platform, modified with the tumor targeting sequence arginine-glycine-aspartate (RGD, Fig. 1 A) was developed and utilized for tumor cell targeting in-vitro and in-vivo.Particles were designed to be injected intravenously, travel to the tumor cell (Fig. 1 B), internalize via α v ß 3 integrin mediated …Web

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Indium-lll-Labeled Platelet Scintigraph in y Carotid …

platelets revealed no evidence of severe in vitro damage as indicated by normal recovery of the labeled platelets in the circulation (median recovery 2 hours after injection 71%) and by occasional ... indium-111 (172 and 247 KeV) were collected with a 15% energy window and stored in a 128 128x matrix in a dedicated computer (PDP 11/34, Digital ...Web

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Subcellular localization of indium-111 in indium-111-labeled …

Indium-111 (/sup 111/In)-oxine has recently been suggested as a new agent for isotopic labeling of platelets. In this paper, the results of in vitro studies on /sup 111/In-oxine uptake by and loss from human platelets as well as function of labeled platelets are presented. /sup 111/In-oxine was rapidly taken up by platelets in a plasma-poor medium, with a mean …Web

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The Auger electron dosimetry of indium-111 in mammalian cells in …

The Auger electron dosimetry of indium-111 in mammalian cells in vitro Most of the radionuclides used in the formulation of radiopharmaceuticals emit Auger electrons when …Web

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Molecular Imaging and Preclinical Studies of Radiolabeled Long …

The aim of this study was to evaluate the potential of indium-111(111 In) radiolabeled DOTA-EB-cRGDfK in α v β 3 integrin-expressing tumors. The human glioblastoma cell line U-87 MG was used to determine the in vitro binding affinity of the radiolabeled peptide.Web

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Indium-111 labeling of leukocytes: a detrimental effect on …

@article{osti_6203551, title = {Indium-111 labeling of leukocytes: a detrimental effect on neutrophil and lymphocyte function and an improved method of ... and mixed leukocytes have been labeled in vitro with /sup 111/In chelated to a nontoxic, water soluble agent 2-mercaptopyridine-N-oxide (Merc). Cells were labeled in isotonic salt-balanced ...Web

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In Vivo Evaluation of Indium-111–Labeled 800CW as a Necrosis …

Thereafter, a reliable radiolabeling procedure was developed and we tested in vitro necrosis-avidity of DOTA-PEG 4-800CW with and without indium-111 labeling. After validation, indium-111–labeled 1 ([111 In]In-DOTA-PEG 4-800CW, from here referred to as [111 In]1) was tested in vivo in the mouse 4T1 breast cancer model that spontaneously ...Web

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Octreoscan (Kit for the Preparation of Indium In 111 …

human hormone, somatostatin. Indium 111 pentetreotide binds to somatostatin In receptors on cell surfaces throughout the body. Within an hour of injection, most of the ... the hormonal effect of Octreoin vitro is one-tenth that of scan octreotide. Since diagnostic imaging doses of indium In 111 pentetreotide are lower thanWeb

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Indium-111 labeled platelets: Studies on preparation

The in vitro radiolabeling of platelets was originally performed with chromium-51 to monitor cellular kinetics. When oxine complexes radiolabeled with indium-111 were …Web

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111 In-Capromab pendetide

The antibody conjugate (Capromab pendetide or CYT-365) was radiolabeled with 111 Indium. 111 In-CYT-356 was approved by the US Food and Drug Administration in 1996 for the detection of prostate carcinoma and soft tissue metastases in prostate cancer patients. ... In Vitro Studies: Testing in Cells and TissuesWeb

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In Vitro and In Vivo Evaluation of 89 Zr-DS-8273a as a

Methods: DS-8273a was radiolabeled with indium-111 and zirconium-89. Radiochemical purity, immunoreactivity, antigen binding affinity and serum stability were assessed in vitro. In vivo biodistribution and pharmacokinetic studies were performed, including SPECT/CT and PET/MR imaging. A dose-escalation study using a PET/MR …Web

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In vitro comparison of renal handling and uptake of two

The aim of the study was to analyze renal handling, rate, and mechanism of renal accumulation of two somatostatin receptor-targeted peptides, [DOTA 0, Tyr 3, Thr 8]-octreotide (DOTA-TATE) and [DOTA 0, 1-Nal 3]-octreotide (DOTA-NOC), labeled with indium-111 using in vitro methods. MethodsWeb

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Indium-111 labeled bleomycin for targeting diagnosis and

The in vitro stability of 111 In-BLM was evaluated by incubation in phosphate buffered saline (PBS, 0.1 M, pH 7.6) and sodium carbonated buffer (SCB, 0.1 M pH 5.5) ... Kalevi JA et al (1996) Indium-111 bleomycin complex for radiomotherapy of head and neck cancer- dosimetric and biokinetic aspects. Eur J Nucl Med 23:631–638.Web

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Localization of indium-111 in human malignant tumor xenografts …

The kinetics of soluble indium-111 ((111)In) in human malignant tumor xenografts and cells was investigated in combination with chelators. Firstly, without chelator, the kinetics of (111)In-chloride was investigated in vitro and in vivo using four human malignant neuroblastoma SK-N-MC, pulmonary papillary adenocarcinoma NCI-H441, pulmonary …Web

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Radiolabeled red blood cells: status, problems, and prospects

The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in …Web

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Octreoscan (Indium in -111 Pentetreotide Kit for Intravenous

Indium In-111 pentetreotide should be tested for labeling yield of radioactivity prior to administration. The product must be used within six hours of preparation. ... In nonclinical pharmacologic studies, the hormonal effect of Octreoscan in vitro is one-tenth that of octreotide. Since diagnostic imaging doses of indium In-111 pentetreotide ...Web

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In Vitro and In Vivo Characterization of Indium-111 and …

Abstract. Cholecystokinin (CCK) receptors of the subtype B (CCK-BR) have been shown to be overexpressed in certain neuroendocrine tumors including medullary …Web

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Indium-111 oxine labelling affects the cellular integrity of

Methods: Murine haematopoietic progenitor cells (10 (6), FDCPmix) were labelled with 0.1 MBq (low dose) or 1.0 MBq (high dose) (111)In-oxine and compared with unlabelled controls. Cellular retention of (111)In, viability and proliferation were determined up to 48 h after labelling. Labelled cells were injected into the cavity of the left or ...Web

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Labeled Leukocyte Imaging: Dawn of an Era (perspective on "Indium-111

In the mid 1970s, the demonstration by Thakur et al. that autologous leukocytes labeled in vitro with 111 In-oxine could image infection in humans was a seminal event. The concept on which this test is based is simple: imaging of a physiologic process, the in vivo migration of radiolabeled leukocytes. ... (perspective on "Indium-111-Labeled ...Web

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Synthesis, characterization and theranostic evaluation of Indium-111

Indium-111 labeled, Trastuzumab-Doxorubicin Conjugated, and APTES-PEG coated magnetic nanoparticles were designed for tumor targeting, drug delivery, controlled drug release, and dual-modal tumor imaging. ... In addition to in vitro assessments of modified SPIONs in SKBR3 cell lines, their theranostic effects were evaluated in HER2 + …Web

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In vitro and in vivo characterization of Indium-111 and

In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging Cancer Biother Radiopharm . 2004 Feb;19(1):93 …Web

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111 Indium-diethylenetriaminepentaacetic acid-folate

In Vitro Studies: Testing in Cells and Tissues [Human nasopharyngeal carcinoma KB cells have a K d of 1.6 nM for FITC-folate ().Cellular uptake of 100 nM 111 In-DTPA-folate was saturable within 10 …Web

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Indium-111 Radiochemical Indium Chloride Solution

111. In. Assay. High resolution gamma spectrometry . at 245.4 keV. PRODUCT SPECIFICATION Chemical Form. Indium chloride in dilute HCl. Normality. 0.05 N ± 0.01 …Web

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In Vivo Evaluation of Indium-111–Labeled 800CW as a Necrosis …

In vitro dead cell binding of 800CW.a Dead or alive 4T1-Luc2 cells in a 96-well plate, treated with either Nat. In-1, 1 a (heated at 70 °C for 30 min), 1, 4, 3, or culture medium.b Fluorescent signal from a, black bars indicate signal from dead cells and white bars indicate signal from alive cells (n = 9).c Dead or alive 4T1-Luc2 cells in a 12-well …Web

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